On September 10th, 2020, the Vaccine monitoring Collaboration for Europe (VAC4EU) and the Brighton Collaboration’s Safety Platform for Emergency vACcines (SPEAC) project jointly held a Scientific webinar on how to assess Vaccine Associated Enhanced Disease (VAED) in epidemiologic studies monitoring COVID-19 vaccines. Speakers provided an update on the Brighton Collaboration’s case definition of VAED and on algorithms for establishing background rates, and participants discussed some of the challenges they face.

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