‘Progress Toward a Global Vaccine Data Network’ is a special article in the Pediatric Infectious Disease Journal. It provides an update on preparations for a global network to monitor the safety and effectiveness of vaccines, including COVID-19 vaccines, across geographically and demographically diverse sites. It covers the need for such a network, how it is coordinated, criteria for participation and plans for capacity development. The need for a common data model and flexible models for analysis are also described.